Ⅰ.科研工作

杜敏敏，博士生导师，国家级青年人才（海外）项目获得者，长期以番茄为主要对象，研究植物激素介导的生长和防御机制，同时还开展番茄分子育种相关的应用研究工作。代表性研究成果包括：1）揭示了生长素介导的双子叶植物幼苗顶端弯钩的形成机制；2）阐明了茉莉酸介导的抗病反应的激活、级联放大及终止的转录调控机制；3）建立了一种快速创制番茄雄性不育系并用于杂交种子生产的技术体系。以第一或通讯作者（含并列）在Science Advances、Annual Review of Plant Biology、Plant Cell（3篇）、Plant Physiology、Plant Journal和Theoretical and Applied Genetics等期刊发表学术论文9篇。相关成果获得中国发明专利2项并申请美国专利1项；参与培育番茄新品种6个。近年来，杜敏敏博士的研究兴趣主要是解析野生番茄优异性状的遗传基础和分子机理，并应用于番茄品种改良。

科研项目

1.中国农业大学杰出人才项目“番茄果实发育及品质形成的时空调控机理” （2022-2027）主持

2.国家自然科学基金面上项目 “bZIP转录因子调控番茄果实心室数目的分子机制及育种应用”（2024-2027）主持

3.海南省自然科学基金创新团队项目“茄果类蔬菜高效单倍体诱导系的创制与应用”（2024-2027）主持

4.国家自然科学基金面上项目 “番茄转录因子JA5负向调控灰霉病抗性反应的分子机制”（2017-2020）主持

5.国家重点研发计划子课题 “番茄杂种优势利用技术与强优势杂交种创制” （2017-2020）主持    

论文及著作

(#first authors, *corresponding authors)

1.Du M#, Bou Daher F#, Liu Y, Steward A, Tillmann M, Zhang X, Wong JH, Ren H, Cohen J, Li C*, Gray W*. Biphasic control of cell expansion by auxin coordinates etiolated seedling development. Science Advances, 2022, 8(2), p.eabj1570.

2.Zhou X#, Gao H, Zhang X, Khashi u Rahman M, Mazzoleni S, Du M*, Wu F*. Plant extracellular self-DNA inhibits growth and induces immunity via the jasmonate signaling pathway. Plant Physiology, 2023, https://doi.org/ 10.1093/plphys/kiad195.

3.Zhou M, Deng L, Yuan G, Zhao W, Ma M, Sun C, Du M*, Li C and Li C. Rapid generation of a tomato male sterility system and its feasible application in hybrid seed production. Theoretical and Applied Genetics, 2023. 136:197

4.Yang H#, Wang H#, Jiang J, Liu M, Liu Z, Tan Y, Zhao T, Zhang H, Chen X, Li J, Wang A*, Du M* and Xu X*. The Sm gene conferring resistance to gray leaf spot disease encodes a NBS-LRR plant resistance protein in tomato. Theoretical and Applied Genetics, 2022.

5.Du M#, Spalding E and Gray W*. Rapid auxin-mediated cell expansion. Annual Review of Plant Biology, 2020, 71:379-402.

6.Du M#*, Zhou K#, Liu Y#, Deng L#, Zhang X, Lin L, Zhou M, Zhao W, Wen C, Xing J, Li C-B* and Li C*. A biotechnology-based male sterility system for hybrid seed production in tomato. Plant Journal, 2020, 102:1090-1100.

7.Sun C#, Deng L#, Du M, Zhao J, Chen Q, Huang T, Jiang H, Li C-B* and Li C*. A transcriptional network promotes anthocyanin biosynthesis in tomato flesh. Molecular Plant, 2020, 13:42-58.

8.Liu Y#, Du M#, Deng L#, Shen J, Fang M, Chen Q, Lu Y, Wang Q, Li C* and Zhai Q*. MYC2 regulates the termination of jasmonate signaling via an autoregulatory negative feedback loop. Plant Cell, 2019, 31:106-127.

9.Wong J#, Spartz A#, Park M, Du M and Gray W*. Mutation of a conserved motif of PP2C.D phosphatases confers SAUR immunity and constitutive activity. Plant Physiology, 2019, 181：353-366.

10.Deng L#, Wang H#, Sun C, Li Q, Jiang H, Du M, Li C-B and Li C. Efficient generation of pink-fruited tomatoes using CRISPR/Cas9 system. Journal of Genetics and Genomics, 2018, 45: 51-54.

11.Du M#, Zhao J#, Tzeng D, Liu Y, Deng L, Zhai Q, Wu F, Huang Z, Zhou M, Wang Q, Chen Q, Zhong S, Li C-B and Li C. MYC2 orchestrates a hierarchical transcriptional cascade that regulates jasmonate-mediated plant immunity in tomato. Plant Cell, 2017, 29:1883-1906.

12.Du M#, Zhai Q#, Deng L, Li S, Li H, Yan L, Huang Z, Wang B, Jiang H, Huang T, Li C-B, Wei J, Kang K, Li J and Li C. Closely-related NAC transcription factors of tomato differentially regulate stomatal closure and reopening during pathogen attack. Plant Cell, 2014, 26: 3167-3184.

13.杜敏敏，周明，邓磊，李传友，李常保.番茄分子育种现状与展望——从基因克隆到品种改良.园艺学报，2017.

授权专利

李常保，杜敏敏，李传友，邓磊, 周明，温常龙. 一种通过基因组编辑创制番茄雄性不育系的方法及其应用.国家发明专利.CN109207505B.